What Causes Congenital Anomalies of the Bladder and Genitalia?
The exact cause of congenital GU anomalies is not completely understood. However, we do know that most anomalies of the reproductive system occur during the 8th week of development and are likely due to the arrest of development of the preliminary structures.
The development of the genitourinary system begins during the third week in pregnancy and carries into the second trimester. The formation of the reproductive tract is closely associated with the development of the urinary system, which is why women with anomalies of the reproductive system commonly have anomalies of the renal system.
Some of the anomalies of the urinary tract and kidney have been shown to be associated with diabetes in pregnancy.
How common are anomalies of the genital and urinary system?
Anomalies of the genital system affect a little over 5 percent of women. Congenital anomalies of the kidneys and urinary tract (CAKUT) affect 4 in 1000 births.